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Appraisal tools should consider the reliability, importance and applicability of the clinical evidence found. According to the Centre for Evidence Based Medicine appraisal should consider these four questions:
There are many checklists available for free to assist with the appraisal of the evidence.
GRADE (Grading of Recommendations, Assessment, Development and Evaluations) is transparent way to evaluate the effectiveness of systematic reviews. Ratings range from high to very low and consider two types of studies; randomized controlled trials and observational studies.